CGx (Hereditary Cancer Genomics) Testing is a specialized genetic test that analyzes inherited genetic mutations that may increase an individual’s risk for developing certain types of cancer. Using Next-Generation Sequencing (NGS), this test examines genes known to be associated with hereditary cancer syndromes, providing valuable insight into cancer risk assessment, early detection, and personalized treatment strategies.

You may benefit from CGx testing if you have:
✅ A personal or family history of cancer diagnosed before the age of 50
✅ A family history of multiple cases of the same type of cancer
✅ A known genetic mutation (e.g., BRCA1/BRCA2) in your family
✅ A personal history of multiple primary cancers
✅ A rare or unusual type of cancer, such as male breast cancer or ovarian cancer
✅ Ashkenazi Jewish ancestry, which is linked to a higher prevalence of BRCA mutations

CGx testing helps identify inherited gene mutations linked to several types of hereditary cancers, including:

1. Breast & Ovarian Cancer

• BRCA1 & BRCA2 mutations (Hereditary Breast and Ovarian Cancer Syndrome – HBOC)
• PALB2, ATM, CHEK2, RAD51D mutations
• TP53 (Li-Fraumeni Syndrome)

2. Colorectal & Gastrointestinal Cancer

• APC (Familial Adenomatous Polyposis – FAP)
• MLH1, MSH2, MSH6, PMS2 (Lynch Syndrome)
• STK11 (Peutz-Jeghers Syndrome)

3. Prostate Cancer

• BRCA2, HOXB13 mutations
• ATM, CHEK2, NBN mutations

4. Pancreatic Cancer

• BRCA1, BRCA2, ATM, PALB2 mutations
• CDKN2A, STK11, TP53 mutations

5. Melanoma (Skin Cancer)

• CDKN2A, BAP1 mutations

6. Endometrial & Uterine Cancer

• Lynch Syndrome genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

7. Kidney Cancer

• VHL (Von Hippel-Lindau Syndrome)
• FH, MET mutations

8. Thyroid Cancer

• RET mutations (Multiple Endocrine Neoplasia – MEN2)
• PTEN (Cowden Syndrome)

9. Brain Tumors & Sarcomas

• TP53 (Li-Fraumeni Syndrome)
• NF1, NF2 (Neurofibromatosis)

🩸 Step 1: Sample Collection – A simple blood or saliva sample is collected at a certified laboratory.
🧬 Step 2: DNA Sequencing – Our Next-Generation Sequencing (NGS) technology analyzes cancer-related genes.
🖥 Step 3: Bioinformatics Analysis – AI-driven software identifies genetic mutations linked to hereditary cancers.
📑 Step 4: Expert Genetic Review – Board-certified geneticists validate and interpret the results.
👩‍⚕️ Step 5: Personalized Report & Consultation – A detailed clinical report is provided to your physician for further guidance.

💡 Early Cancer Detection – Helps identify high-risk individuals before symptoms develop.
🔬 Personalized Treatment Options – Guides targeted therapies and treatment plans.
👪 Family Risk Assessment – Assists in determining cancer risks for relatives.
🧑‍⚕️ Preventive Measures & Screening Recommendations – Enables early intervention strategies.
📊 Clinical Trial Access – Identifies eligibility for new treatments and studies.

• Pathogenic Variant Identified – A confirmed inherited mutation linked to increased cancer risk. Preventive care and risk reduction strategies are advised.
• Likely Pathogenic Variant – A probable mutation requiring clinical follow-up for risk assessment.
• Variant of Uncertain Significance (VUS) – The mutation’s impact is unclear; further family testing or research may be needed.
• No Pathogenic Variant Detected – This does not eliminate cancer risk but indicates no known inherited mutations.

• Risk Reduction Strategies: Lifestyle changes, risk-reducing surgeries, medications (e.g., Tamoxifen for BRCA mutation carriers).
• Increased Surveillance: Early and more frequent screenings such as mammograms, colonoscopies, PSA tests, or MRI scans.
• Genetic Counseling: Discussion of implications for you and your family members.
• Targeted Treatment: Some genetic findings may qualify patients for personalized treatments such as PARP inhibitors for BRCA-positive cancers.
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• CGx testing is often covered by insurance if a person meets medical necessity criteria. Our team can assist with pre-authorization, insurance claims, and financial assistance programs.

• ✔ Comprehensive Genetic Panels – Covers all major hereditary cancer genes
  ✔ CLIA-Certified & CAP-Accredited Laboratory – Ensures the highest testing accuracy
  ✔ Rapid Turnaround Time – Results available within 2-4 weeks
  ✔ Expert Genetic Counseling – Support to help you understand and act on results
  ✔ Advanced NGS Technology – High-depth sequencing for the most accurate results